Metabolism of D-glucuronolactone in mammalian systems. Inhibitory properties of the products of D-glucuronolactone-dehydrogenase action.
نویسنده
چکیده
1. d-Glucuronolactone was converted into d-glucaro-(1-->4)-lactone, a beta-glucuronidase inhibitor, probably via the intermediate d-glucaro-(1-->4)-(6-->3)-dilactone, by a dehydrogenase in human-liver extracts. 2. Similar experiments with mouse-liver extracts appeared to yield only d-glucaric acid or a non-inhibitory lactone. 3. A strong beta-glucuronidase inhibitor was present in mouse liver after the intraperitoneal administration of d-glucuronolactone. 4. d-Glucarodilactone decomposed spontaneously in aqueous solution to give 25% of d-glucaro-(1-->4)-lactone; the percentage conversion was unaffected by human-liver homogenates. but considerably increased by mouse-liver or pig-liver fractions.
منابع مشابه
Metabolism of D-glucuronolactone in Mammalian Systems. 3. Further Studies of D-glucuronolactone Dehydrogenase of Rat Liver.
متن کامل
Alterations in the D-glucuronic Acid Pathway and Drug Metabolism W Exogenous Compounds
Treatment of guinea-pigs with disulfiram for 8 days resulted in a significant enhancement of the in vitro activities of the N-demethylation of aminopyrine and the glucuronyl conjugation of p-mtrophenol. This increase was accompanied by an induction of liver growth and an increase in microsomal protein content. It might be concluded that disulfiram has inductive properties with respect to drug m...
متن کاملAlterations in the D-glucuronic Acid Pathway and Drug Metabolism W Exogenous Compounds
Treatment of guinea-pigs with disulfiram for 8 days resulted in a significant enhancement of the in vitro activities of the N-demethylation of aminopyrine and the glucuronyl conjugation of p-mtrophenol. This increase was accompanied by an induction of liver growth and an increase in microsomal protein content. It might be concluded that disulfiram has inductive properties with respect to drug m...
متن کاملAlterations in the D-glucuronic Acid Pathway and Drug Metabolism W Exogenous Compounds
Treatment of guinea-pigs with disulfiram for 8 days resulted in a significant enhancement of the in vitro activities of the N-demethylation of aminopyrine and the glucuronyl conjugation of p-mtrophenol. This increase was accompanied by an induction of liver growth and an increase in microsomal protein content. It might be concluded that disulfiram has inductive properties with respect to drug m...
متن کاملAlterations in the D-glucuronic Acid Pathway and Drug Metabolism W Exogenous Compounds
Treatment of guinea-pigs with disulfiram for 8 days resulted in a significant enhancement of the in vitro activities of the N-demethylation of aminopyrine and the glucuronyl conjugation of p-mtrophenol. This increase was accompanied by an induction of liver growth and an increase in microsomal protein content. It might be concluded that disulfiram has inductive properties with respect to drug m...
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عنوان ژورنال:
- The Biochemical journal
دوره 99 1 شماره
صفحات -
تاریخ انتشار 1966